KISSPEPTIN 10MG

Description

Kisspeptin-10 10mg research peptide — Canada

Researched & reviewed by the SPO Quality Team · Last reviewed: 30 September 2026

Kisspeptin-10 is the ten-amino-acid C-terminal piece of the peptides that the human KISS1 gene encodes, and the shortest fragment that fully activates their receptor, KISS1R (GPR54)^{[1, 4]}. Mutations that silence that receptor stop puberty in humans and mice^[2], which made kisspeptin a reference tool in reproductive neuroendocrinology. This listing is one sealed vial of lyophilized human kisspeptin-10 at a 10mg labelled amount, supplied for laboratory research only.

Full research overview, 25-reference study table & limits of the evidence → Kisspeptin-10 in Canada: research guide

Identity at a glance

Batch documentation

A batch-specific COA for this strength has not been posted yet — see the COA library (/coa/). No other product’s report is shown here in its place. When a report for a kisspeptin-10 lot is issued it will be embedded on this page. Note that the “10” in the name counts residues; the 10mg is the vial’s labelled content, and a measured amount belongs only on a report.

What researchers have looked at

• Receptor signalling (cell culture, 2001): kisspeptins bound rat and human GPR54 at low-nanomolar affinity and set off phosphoinositide hydrolysis, calcium release and MAP-kinase phosphorylation while slowing cell proliferation^[1].
• Site of action (mouse and sheep, 2005): the receptor sits on GnRH neurons, kisspeptin has no effect in receptor-knockout mice, and in sheep it released GnRH directly into cerebrospinal fluid^[3].
• Healthy men (2011): kisspeptin-10 raised LH dose-dependently with a bell-shaped curve, triggered an immediate LH pulse and reset the timing of the hypothalamic GnRH pulse generator^{[4, 5]}.
• Repeated exposure (women, 2009; prepubertal rats, 2011): the LH response to kisspeptin-54 shrank after two weeks^[6]; twelve days of kisspeptin-10 in immature rats lowered LH and testosterone and damaged seminiferous tubules^[7].
• Status (2026 review): proposed as a diagnostic probe of hypothalamic function; not an approved medicine anywhere^[8].

These are literature findings about the compound in the models named. They are not properties of this vial, and no benefit is claimed for it.

Storage and handling

• Sealed vial at −20 °C for long-term storage (the site states up to 24 months as dry powder); cool, dry and dark for brief holds; avoid freeze–thaw cycling.
• Solutions are less stable than powder — the parent peptide’s plasma half-life is under half an hour — so prepare only what an experiment needs. Reconstitution and handling protocols belong to the researcher and are not described on this site.

Other reproductive-axis and GH-axis listings are in the research catalogue. Orders ship from inside Canada by Canada Post; the shipping policy has the dispatch cut-off, delivery times and the free-shipping threshold. The rest of the range is on the page where you can buy peptides online in Canada.

Related reading: Kisspeptin vs GnRH: Two Steps on the Reproductive Axis · Kisspeptin-10 Research Guide: Structure, KISS1R and Study Models

Frequently asked questions

Can I buy Kisspeptin-10 10mg in Canada?

Yes. Shop Peptides Online supplies the 10mg vial as research-grade lyophilized human kisspeptin-10 and ships it from inside Canada by Canada Post, with no customs step. It is sold for laboratory research only; kisspeptin-10 has no approved drug form anywhere.

Is there a COA for Kisspeptin-10 10mg?

Not yet. A batch-specific certificate for this strength has not been posted, and no other product’s report is shown in its place. When an independent report for a kisspeptin-10 lot is issued it will be embedded on this page; look for the species form, an HPLC purity figure and a mass-spectrometry match to 1302.4.

How should Kisspeptin-10 be stored?

In the sealed vial at −20 °C for long-term storage (the site states stability up to 24 months as lyophilized powder); cool, dry and dark for short holds; no repeated freeze–thaw. The sequence contains tyrosine and tryptophan, which oxidise, so keep solutions fresh and protected from light.

Is Kisspeptin-10 for human use?

No. This vial is research-grade material for laboratory use only, not for human or animal consumption. Kisspeptin-10 is not approved by Health Canada, the FDA or the EMA; its human literature consists of small academic physiology studies (PMIDs 21632807, 21470997) and reviews calling for trials (PMID 39834030). Shop Peptides Online provides no dosing or administration guidance.

References

1. Kotani M, Detheux M et al. (2001). The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. PMID 11457843
2. Seminara SB, Messager S et al. (2003). The GPR54 gene as a regulator of puberty. N Engl J Med. PMID 14573733
3. Messager S, Chatzidaki EE et al. (2005). Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci U S A. PMID 15665093
4. George JT, Veldhuis JD et al. (2011). Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J Clin Endocrinol Metab. PMID 21632807
5. Chan YM, Butler JP et al. (2011). Kisspeptin resets the hypothalamic GnRH clock in men. J Clin Endocrinol Metab. PMID 21470997
6. Jayasena CN, Nijher GM et al. (2009). Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. J Clin Endocrinol Metab. PMID 19820030
7. Ramzan F, Qureshi IZ (2011). Intraperitoneal kisspeptin-10 administration induces dose-dependent degenerative changes in maturing rat testes. Life Sci. PMID 21112339
8. Pierret ACS, Patel AH et al. (2026). Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders. Andrology. PMID 39834030

For laboratory research use only. Not for human or animal consumption. This description identifies the material and summarises published preclinical and clinical literature on the compound; it makes no claim of efficacy or safety for the material sold.