GHK-CU (Pen)

Description

Buy GHK-Cu pen in Canada — research format

Researched & reviewed by the SPO Quality Team · Last reviewed: 30 September 2026

The pen carries the same material as the GHK-Cu vials — glycyl-L-histidyl-L-lysine bound to copper(II) — in a pre-filled research format with two fills, 50mg and 100mg. The peptide was proposed in 1980 to work by ferrying copper into cells^[1], and later work in rat wound chambers, human fibroblasts and mouse injury models has kept that copper-peptide pairing at the centre of the story^{[2, 4, 5]}. A 2026 review argues that “GHK-Cu” is often sold and studied without its coordination state being defined^[7] — a point that applies to any format, pen included. This is research-grade material for laboratory use only; the pen is a handling convenience, not a medical device.

GHK-Cu pen for sale in Canada: both fills (50mg and 100mg) are in stock and ship from inside Canada. Choose a fill above to order; for laboratory research use only.

Full research overview, study table & references → GHK-Cu in Canada: research guide

Identity at a glance

Batch documentation

A batch-specific COA for this format has not been posted yet — see the COA library (/coa/). The library’s only GHK-Cu entry is the report for the 100mg vial (Janoshik #218248); no entry exists for the 50mg or 100mg pen, so that report is not reproduced here. When a pen-lot report is issued it will be embedded on this page.

What researchers have looked at

• Copper transport (1980): GHK co-isolated with near-equimolar copper, several related tripeptides were almost as active, and the sequence resembled the copper-binding sites of albumin — hence the copper-uptake hypothesis^[1].
• Rat wound chambers (1999–2000): GHK-Cu changed the pattern of matrix metalloproteinase-2 and -9 expression without altering collagenase activity^[2], and increased wound-tissue dry weight, type I collagen and glycosaminoglycans, shifting the balance toward chondroitin and dermatan sulfate and the small proteoglycans decorin and biglycan^[3].
• Irradiated human fibroblasts (2005): in serum-free culture, cells from irradiated head-and-neck surgery specimens doubled faster with GHK-Cu and produced more basic FGF and VEGF early on^[4].
• Mouse lung and colon injury (2016, 2025): in LPS-induced acute lung injury GHK-Cu lowered reactive oxygen species, TNF-α and IL-6 via NF-κB p65 and p38 MAPK and reduced inflammatory-cell infiltration^[5]; in DSS colitis it was examined for effects on tight-junction proteins and the SIRT1/STAT3 pathway^[6].

Each item is a cell or rodent finding about the compound, reported as literature. It is not a property of this pen, and no effect is claimed for the material sold.

Storage and handling

• Store the pen as its label directs; the site’s general guidance for lyophilized GHK-Cu is −20 °C for long-term storage (stated stability up to 24 months) and cool, dry, dark conditions for short holds, without repeated freeze–thaw.
• Log the fill (50mg or 100mg), the lot and the dates received and opened. Copper peptides are pH-sensitive in solution; prepare only what an experiment needs. Handling protocols are the researcher’s responsibility and are not described on this site.

Vial formats: GHK-Cu 50MG · GHK-Cu 100MG (posted COA). Shipping is from inside Canada by Canada Post; the shipping policy lists cut-off, delivery times and the free-shipping threshold. Everything we carry is on the page where you can buy peptides online in Canada.

Frequently asked questions

Can I buy the GHK-Cu pen in Canada?

Yes. Shop Peptides Online supplies the GHK-Cu pen in 50mg and 100mg fills as research-grade material, shipped from inside Canada by Canada Post. It is sold for laboratory research only.

Is there a COA for the GHK-Cu pen?

No. The COA library lists a Janoshik report for the GHK-Cu 100mg vial only; there is no library entry for either pen fill, so no report is shown here. A batch-specific COA for this format has not been posted yet — see the COA library. If a pen-lot report is issued it will be embedded on this page.

What is the pen format?

The same lyophilized GHK-Cu complex supplied in a pre-filled research pen for laboratories that want repeatable, logged handling, offered in two fills. The 50mg and 100mg vials are listed separately. A fill figure is a nominal amount; only a batch report gives a measured value.

Is the GHK-Cu pen for human use?

No. It is research-grade material for laboratory use only, not for human or animal consumption. GHK-Cu has no approved drug form anywhere; the 2026 Pharmaceutics review notes that products are often sold and studied without their coordination state being defined (PMID 42797253); and Shop Peptides Online provides no dosing or administration guidance.

References

1. Pickart L, Freedman JH et al. (1980). Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells. Nature. PMID 7453802
2. Siméon A, Monier F et al. (1999). Expression and activation of matrix metalloproteinases in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. J Invest Dermatol. PMID 10383745
3. Siméon A, Wegrowski Y et al. (2000). Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+). J Invest Dermatol. PMID 11121126
4. Pollard JD, Quan S et al. (2005). Effects of copper tripeptide on the growth and expression of growth factors by normal and irradiated fibroblasts. Arch Facial Plast Surg. PMID 15655171
5. Park JR, Lee H et al. (2016). The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice. Oncotarget. PMID 27517151
6. Mao S, Huang J et al. (2025). Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms. Front Pharmacol. PMID 40672369
7. Mateescu DM, Gavrilescu DM et al. (2026). GHK-Cu as a Bioactive Metallopeptide and Drug-Delivery Cargo: Coordination Chemistry, Formulation Science, Therapeutic Evidence, and a Translational Roadmap. Pharmaceutics. PMID 42797253

For laboratory research use only; not for human or animal consumption. This listing identifies the material, its documentation status and the compound’s published literature, and makes no claim of efficacy or safety.