GHK-CU 50MG

Description

GHK-Cu 50mg research peptide — Canada

Researched & reviewed by the SPO Quality Team · Last reviewed: 30 September 2026

GHK-Cu is the copper(II) complex of a tripeptide, glycyl-L-histidyl-L-lysine, that Loren Pickart first noticed in 1973 as a fraction of human serum that kept liver cells alive in culture^[1]. Copper binds the peptide one-to-one through nitrogen atoms including the histidine imidazole^[2], and it is this complex — not the bare peptide — that most of the fibroblast and rodent wound literature describes^{[3, 4]}. Fifty years on it is a cosmetic ingredient and a research reagent with no approved medical form^[7]. This listing is one sealed vial of lyophilized GHK-Cu at a 50mg labelled amount, for laboratory research only.

Full research overview, study table & references → GHK-Cu in Canada: research guide

Identity at a glance

Batch documentation

A batch-specific COA for this strength has not been posted yet — see the COA library (/coa/). The library’s GHK-Cu document (Janoshik #218248) was generated on the 100mg vial batch; a 50 mg lot is a separate preparation and that report is not shown here. A 50 mg batch report will be embedded when one is issued.

What researchers have looked at

• Fibroblast cultures (1988): the complex raised collagen synthesis at picomolar-to-nanomolar concentrations without changing cell number^[3].
• Rat wound chambers (1993): connective tissue deposited in subcutaneous mesh cylinders increased with GHK-Cu concentration — dry weight, protein, collagen, DNA, elastin and glycosaminoglycans, with matching collagen and TGF-β mRNA^[4].
• Human venous ulcers (1992, 86 patients): a randomised, evaluator-blinded trial found silver sulfadiazine cream reduced ulcer size while a GHK-Cu cream did no better than placebo^[5].
• Rat ACL reconstruction (2015, 72 rats): intra-articular GHK-Cu reduced knee laxity at six weeks; the study’s own title calls the improvement transient^[6].
• 2026 systematic review: four decades of preclinical data, a human literature that is “thin and fragmented”, and a call for adequately powered trials^[7].

Those are published findings about the compound in the systems named; none is a property of this vial, and no benefit is claimed for the material sold.

Storage and handling

• Sealed vial at −20 °C for long-term storage (the site states up to 24 months as dry powder); cool, dry and dark for brief holds; no repeated freeze–thaw.
• The blue-violet colour of a GHK-Cu solution comes from the copper complex; its coordination shifts with pH^[2], so record the buffer used and make solutions fresh. Reconstitution and handling protocols belong to the researcher and are not described on this site.

Also listed: GHK-Cu 100MG (posted COA) · GHK-Cu pen · blends GLOW and KLOW. Orders ship from inside Canada by Canada Post; the shipping policy has dispatch cut-off, delivery times and the free-shipping threshold. The full range is on the page where you can buy peptides online in Canada.

Related reading: BPC-157 vs GHK-Cu: Two Repair Peptides, Two Different Mechanisms

GHK-Cu is often compared with TB-500, the thymosin beta-4 fragment; our TB-500 vs GHK-Cu comparison sets the copper carrier and the actin-binding fragment side by side.

Frequently asked questions

Can I buy GHK-Cu 50mg in Canada?

Yes. Shop Peptides Online supplies the 50mg vial of GHK-Cu as research-grade lyophilized material and ships it from inside Canada by Canada Post. It is sold for laboratory research only; GHK-Cu has no approved drug form.

Is there a COA for GHK-Cu 50mg?

Not yet for this strength. The COA library carries a Janoshik report for the 100mg vial (report #218248); that document describes the 100 mg batch and is not evidence for the 50 mg lot, so it is not reproduced here. A 50 mg report will be embedded when one is issued.

How should GHK-Cu be stored?

Sealed vial at −20 °C for long-term storage (the site states stability up to 24 months as lyophilized powder); cool, dry and dark for short holds; avoid repeated freeze–thaw. In solution the copper’s coordination changes with pH (PMID 6291585), so buffer choice matters and solutions should be made fresh.

Is GHK-Cu for human use?

No — the vial is research-grade material for laboratory work, not for human or animal consumption. GHK-Cu is not a drug in Canada, the US or the EU; the one sizeable randomised trial of a GHK-Cu cream, in venous ulcers, found no difference from placebo (PMID 1495150); and Shop Peptides Online provides no dosing or administration guidance.

References

1. Pickart L, Thaler MM (1973). Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver. Nat New Biol. PMID 4349963
2. Freedman JH, Pickart L et al. (1982). Structure of the Glycyl-L-histidyl-L-lysine–copper(II) complex in solution. Biochemistry. PMID 6291585
3. Maquart FX, Pickart L et al. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. PMID 3169264
4. Maquart FX, Bellon G et al. (1993). In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds. J Clin Invest. PMID 8227353
5. Bishop JB, Phillips LG et al. (1992). A prospective randomized evaluator-blinded trial of two potential wound healing agents for the treatment of venous stasis ulcers. J Vasc Surg. PMID 1495150
6. Fu SC, Cheuk YC et al. (2015). Tripeptide-copper complex GHK-Cu (II) transiently improved healing outcome in a rat model of ACL reconstruction. J Orthop Res. PMID 25731775
7. Najafi N, Maatouk H et al. (2026). A Systematic Review of the Mechanisms and Therapeutic Applications of GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper Complex) in Topical Microneedle Delivery: A Case for Expanded Clinical Trials. Arch Intern Med Res. PMID 42787770

For laboratory research use only. Not for human or animal consumption. This description identifies the material and summarises published literature on the compound; it makes no claim of efficacy or safety for the material sold.