MOTS-C 40MG

Description

MOTS-c 40mg research peptide — Canada

Researched & reviewed by the SPO Quality Team · Last reviewed: 30 September 2026

The largest MOTS-c vial we stock, for laboratories running larger assay series. MOTS-c is a sixteen-amino-acid peptide encoded in the mitochondrial 12S rRNA gene; much of the recent literature concerns its relationship with exercise — the body’s own MOTS-c rises with training in mice and in people^{[1, 2]} — and a natural variant linked to muscle-fibre type^[3]. Synthetic lyophilized peptide, sealed vial, laboratory research only.

Full research overview, study table & references → MOTS-c in Canada: research guide

Identity at a glance

Batch documentation: a batch-specific COA for this strength has not been posted yet — see the COA library.

What researchers have looked at

• Exercise and ageing (2021): in mice, MOTS-c improved physical performance at 2, 12 and 22 months and, begun at 23.5 months, extended healthspan; in humans, exercise induced MOTS-c in skeletal muscle and circulation^[1].
• Training in rodents (2022): 4–8 weeks of voluntary wheel running raised muscle MOTS-c protein 1.5- to 5-fold, sustained through 4–6 weeks of detraining; a single administration to untrained mice improved running time by 12% and distance by 15% in an acute test^[2].
• Fibre type and a natural variant (2022): Japanese carriers of the K14Q variant had more fast-twitch MHC-IIx fibre and higher leg torque, and the allele was more frequent in sprint/power athletes than endurance athletes^[3].
• Human plasma after an exercise programme (2021): 16 weeks of aerobic and resistance exercise raised plasma MOTS-c in non-Hispanic White but not Hispanic breast-cancer survivors^[4]. Limits: all human data concern endogenous MOTS-c; the nuclear-translocation mechanism is from cell work^[5].

Storage and handling

• Keep the sealed vial at −20 °C for long-term storage (site guidance: up to 24 months as powder); short-term cool, dry and dark; do not freeze–thaw repeatedly.
• Water-soluble. Larger vials are usually aliquoted after reconstitution to avoid repeated warming; bacteriostatic water is listed separately. Protocols are the researcher’s own.

Other strengths: MOTS-C 10MG · MOTS-C 20MG · MOTS-C (Pen). Shipped by Canada Post within Canada (policy); browse everything else on the buy peptides online in Canada page.

Frequently asked questions

Can I buy MOTS-c 40mg in Canada?

Yes. The 40 mg vial is our largest single MOTS-c listing and ships by Canada Post from inside Canada. It is supplied for laboratory research only.

Is there a certificate of analysis for the 40mg vial?

Not yet. No batch-specific report for the 40 mg strength — or any MOTS-c listing — is in the COA library at the time of writing; the page will be updated when one is posted.

Why is MOTS-c called an exercise-related peptide?

Because exercise raises the body’s own MOTS-c: in humans, muscle and circulating levels rose after exercise (PMID 33473109), and in rodents 4–8 weeks of voluntary running raised muscle MOTS-c protein 1.5- to 5-fold (PMID 35808870). Those are observations about endogenous MOTS-c, not evidence about the synthetic peptide in people.

Is MOTS-c for human use?

No. There is no approved product and no published trial of synthetic MOTS-c in humans; the human data are measurements of endogenous peptide and gene variants (PMIDs 34413391, 34728329). Laboratory research only; no dosing or administration guidance is provided.

Cited

1. Reynolds et al. (2021), Nature communications — PMID 33473109
2. Hyatt et al. (2022), Physiological reports — PMID 35808870
3. Kumagai et al. (2022), Biochimica et biophysica acta. General subjects — PMID 34728329
4. Dieli-Conwright et al. (2021), Scientific reports — PMID 34413391
5. Kim et al. (2018), Cell metabolism — PMID 29983246

For laboratory research use only. Not for human or animal consumption. No dosing, administration or protocol information is provided, and nothing here is a claim of efficacy or safety in humans.