Description
MOTS-c 10mg research peptide — Canada
Researched & reviewed by the SPO Quality Team · Last reviewed: 30 September 2026
MOTS-c is the peptide that showed the mitochondrial genome can encode signals of its own: sixteen residues (MRWQEMGYIFYPRKLR) read from a short open reading frame inside the 12S ribosomal RNA gene, first described in 2015[1]. The 10mg vial is the entry strength in our range. Synthetic lyophilized powder, one sealed vial, laboratory research only.
Full research overview, study table & references → MOTS-c in Canada: research guide
Identity at a glance
| Name |
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) |
| Sequence |
MRWQEMGYIFYPRKLR (16 aa) |
| Formula / MW |
C101H152N28O22S2 · 2174.6 g/mol |
| CAS / UNII |
1627580-64-6 / A5CV6JFB78 |
| PubChem CID |
146675088 |
| Declared content |
10 mg per vial (label value; no measured value on file) |
Batch documentation: a batch-specific COA for this strength has not been posted yet — see the COA library.
What researchers have looked at
- Metabolism in mice (2015): the discovery study found that MOTS-c inhibits the folate cycle and de-novo purine synthesis, activating AMPK, and that treated mice were protected from age-dependent and diet-induced insulin resistance and from diet-induced obesity[1].
- Nuclear signalling (2018): under glucose restriction the peptide moved into the nucleus in an AMPK-dependent way and regulated antioxidant-response genes with NRF2[2].
- Ageing mice and exercise (2021): MOTS-c enhanced physical performance in 2-, 12- and 22-month-old mice, and in humans exercise raised endogenous MOTS-c in muscle and blood[3].
- Limits: the human evidence is observational — for instance plasma MOTS-c in ten lean and ten obese adults[4] — and reviews state that no clinical application has been developed[5].
Storage and handling
- Sealed vial at −20 °C for long-term storage (site guidance: up to 24 months as dry powder); cool, dry and dark for short periods; no repeated freeze–thaw.
- Water-soluble; bacteriostatic water is listed separately. Protocols are the researcher’s own.
Other strengths: MOTS-C 20MG · MOTS-C 40MG · MOTS-C (Pen). Ships by Canada Post from inside Canada (shipping policy); the full range is on our buy peptides online in Canada page.
Related reading: MOTS-c vs Humanin: two mitochondrial-derived peptides compared
Frequently asked questions
Can I buy MOTS-c 10mg in Canada?
Yes. This vial ships from inside Canada by Canada Post, with no customs hold. It is supplied for laboratory research only; MOTS-c has no approved product anywhere.
Is a COA posted for the MOTS-c 10mg vial?
Not at the time of writing. No batch report for any MOTS-c listing is in the COA library, and this page does not borrow another product’s document. It will be updated when a report is posted.
What was MOTS-c discovered to do in mice?
In the 2015 discovery paper, MOTS-c treatment prevented age-dependent and high-fat-diet-induced insulin resistance and diet-induced obesity in mice, acting on skeletal muscle through the folate cycle and AMPK (PMID 25738459). These are mouse findings, not claims about people.
Is MOTS-c for human use?
No. No published trial has given synthetic MOTS-c to people; human studies measured the body’s own peptide (PMID 29593067). Reviews note that no clinical method of using it has been developed (PMID 36761202). This vial is for laboratory research; no dosing or administration guidance is given.
Cited
- Lee et al. (2015), Cell metabolism — PMID 25738459
- Kim et al. (2018), Cell metabolism — PMID 29983246
- Reynolds et al. (2021), Nature communications — PMID 33473109
- Cataldo et al. (2018), Journal of investigative medicine : the official publication of the American Federation for Clinical Research — PMID 29593067
- Zheng et al. (2023), Frontiers in endocrinology — PMID 36761202
For laboratory research use only. Not for human or animal consumption. No dosing, administration or protocol information is provided, and nothing here is a claim of efficacy or safety in humans.
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product card was clear. I could see the size, price, and docs without clicking around forever.
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the MOTS-C 10mg listing answered most of my questions. the product card made it easy to compare sizes. site feels much easier than a lot of peptide shops.
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MOTS-C 10mg was easy to find on the site. COA info was easy to spot before checkout. site feels much easier than a lot of peptide shops.
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grabbed MOTS-C 10mg after comparing a few listings. the product card made it easy to compare sizes. clean experience.
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liked the MOTS-C listing. package l&ed in good shape and the email updates were on time.
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ordered MOTS-C 10mg and the whole thing was pretty smooth. the batch documentation was easier to read than most sites. thats all I needed.
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got MOTS-C 10mg in my cart without having to hunt around. the page felt clean, especially the COA section. no issues from my side.
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no weird checkout issues. MOTS-C 10mg showed up as listed.
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not much to complain about with MOTS-C 10mg. the checkout email and tracking lined up fine. worked out well.
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the MOTS-C 10mg listing answered most of my questions. the bottle image and size info made it easy to double check. pretty straightforward.
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ordered MOTS-C 10mg and the whole thing was pretty smooth. shipping updates were clear, no guessing game. good enough for a reorder.